Essential Tremor Treatment Report

This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects

Last updated: 5 years ago

News

Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
New radiation therapy shows promise for treating essential tremor Jun 14, 2019

Research

Clinical Trials

The Use of the CUE1/CUE1+ in People With Parkinson’s Disease and Related Disorders Nov 21, 2024
Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study Nov 8, 2024
A Study to Evaluate the Safety and Efficacy of Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor Nov 6, 2024
Ultrasound Neuromodulation in Essential Tremor Sep 24, 2024
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson’s Disease and Essential Tremor Aug 26, 2024
Motor Network Physiology Aug 7, 2024
Impact of Sensory Electrical Stimulation on Sensation and Tremor May 24, 2024
The Effect of Alcohol on Common Tremor Syndromes May 7, 2024
Nonlinear Absorber in Essential Tremor Treatment May 2, 2024
The Development of a System for the Measurement of Tremor Apr 26, 2024
Upper Limb Tremor Reduction in Essential Tremor Patients Apr 2, 2024
3-D Tractography FUS Ablation for Essential Tremor Mar 26, 2024
Directional Bilateral Thalamic Patterned Stimulation (Chronos) Mar 22, 2024
Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study. Mar 15, 2024
Acamprosate and Methazolamide for Essential Tremor Mar 15, 2024
Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor Jan 31, 2024
Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor Nov 27, 2023
Essential 3 – Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET) Oct 17, 2023
Prospective Study for Symptomatic Relief of ET With Cala Therapy Oct 12, 2023
Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson’s Disease and Essential Tremor Sep 13, 2023
A Study of Wearable Device in Essential Tremor Patients Aug 4, 2023
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET Aug 1, 2023
Investigating LFP Correlates of TUS in Patients With Movement Disorders Jul 31, 2023
GyroGlove Use in Essential Tremor Patients Jul 24, 2023
The Development of a System for Measurement of Tremor Jul 21, 2023
Cala ONE Device for Essential Tremor Jul 18, 2023
Coordinated Reset Deep Brain Stimulation for Essential Tremor Jun 9, 2023
Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson’s Tremor May 6, 2023
Evaluation of Bilateral Gamma Knife Thalamotomy in Patients Presenting With Severe Essential Tremor Apr 14, 2023
Atlas Predicted DBS Settings in Essential Tremor Mar 27, 2023
Transcranial Ultrasound Therapy of Essential Tremor Feb 23, 2023
Electroclinical Correlates in Essential Tremor Jan 5, 2023
Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Dec 12, 2022
MRgFUS Thalamotomy for Therapy-Resistant Tremor-related Disease With Low SDR Value Nov 22, 2022
Gamma Knife Radiosurgery for Treatment of Essential Tremor Nov 22, 2022
RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor Sep 14, 2022
Algorithms for Programming DBS Systems for ET Aug 4, 2022
Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands Jul 29, 2022
Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor Jul 26, 2022
Evaluate SAGE-547 in Participants With Essential Tremor Jun 29, 2022
tSMS in Essential Tremor Jun 6, 2022
The Swedish Essential Tremor (SWEET) Trial May 25, 2022
A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
New Stereotactic Frame System for Neurosurgery Oct 14, 2021
ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
[18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
Cortical-Basal Ganglia Speech Networks Aug 9, 2021
Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
Directional Versus Nondirectional DBS for ET Apr 2, 2021
Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021

Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
Alternating Current Stimulation for Essential Tremor Sep 2, 2020
Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
Trial of Cannabis for Essential Tremor May 29, 2020

Projects

Wearable-Sensor Driven Responsive Deep Brain Stimulation for the Improved Treatment of Essential Tremor May 15, 2020

Discussion

Essential Tremor – Reddit

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